ISRCTN11195489
Active, not recruiting
未知
nderstanding Brain Inflammation in Cognitive Problems (BRIC)
ewcastle upon Tyne Hospitals NHS Foundation Trust0 sites110 target enrollmentJuly 9, 2024
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Dementia with Lewy bodies
- Sponsor
- ewcastle upon Tyne Hospitals NHS Foundation Trust
- Enrollment
- 110
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •MCI\-LB/DLB group:
- •1\. Age \=60 years
- •2\. Fulfil criteria for probable MCI\-LB (McKeith et al., 2020\) or DLB (McKeith et al., 2017\)
- •3\. Capacity to consent to participation in the study
- •4\. MMSE \=20
- •5\. If on cholinesterase inhibitors and/or memantine, stable dose for 3 months
- •Control group:
- •1\. Age \=60 years
- •2\. MMSE \=27
- •3\. No evidence of mild cognitive impairment or dementia
Exclusion Criteria
- •1\. Active systemic inflammatory disease
- •2\. Active autoimmune disease
- •3\. Taking immune system modifying medications (e.g., oral steroids or tumour necrosis factor inhibitors)
- •4\. Taking incretin analogues (e.g., liraglutide), minocycline or other microglial suppressing agents
- •5\. History of clinical stroke
- •6\. Current major depression
- •7\. History of bipolar disorder, non\-organic psychosis (e.g., longstanding schizophrenia) or recurrent severe depression
- •8\. Chronic migraine
Outcomes
Primary Outcomes
Not specified
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