nderstanding Brain Inflammation in Cognitive Problems (BRIC)

ewcastle upon Tyne Hospitals NHS Foundation Trust0 个研究点目标入组 110 人开始时间: 2024年7月9日最近更新: 2024年9月2日

适应症

试验速览

暂无简介。

•MCI-LB/DLB group:
•1. Age =60 years
•2. Fulfil criteria for probable MCI-LB (McKeith et al., 2020) or DLB (McKeith et al., 2017)
•3. Capacity to consent to participation in the study
•4. MMSE =20
•5. If on cholinesterase inhibitors and/or memantine, stable dose for 3 months
•Control group:
•1. Age =60 years
•2. MMSE =27
•3. No evidence of mild cognitive impairment or dementia

•1. Active systemic inflammatory disease
•2. Active autoimmune disease
•3. Taking immune system modifying medications (e.g., oral steroids or tumour necrosis factor inhibitors)
•4. Taking incretin analogues (e.g., liraglutide), minocycline or other microglial suppressing agents
•5. History of clinical stroke
•6. Current major depression
•7. History of bipolar disorder, non-organic psychosis (e.g., longstanding schizophrenia) or recurrent severe depression
•8. Chronic migraine

发起方

ewcastle upon Tyne Hospitals NHS Foundation Trust