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Clinical Trials/ACTRN12614000411640
ACTRN12614000411640
Recruiting
Phase 2

Randomised controlled trial of N-Acetyl-Cysteine vs placebo for the prevention of Post Operative Cognitive Dysfunction in major elective non-cardiac surgery

The Geelong Hospital0 sites370 target enrollmentApril 15, 2014
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ConditionsPost Operative Cognitive DysfunctionSurgical Stress ResponsePost Operative Mood DisorderPost surgical painAnaesthesiology - AnaestheticsMental Health - Studies of normal psychology, cognitive function and behaviourSurgery - Other surgery

Overview

Phase
Phase 2
Intervention
Not specified
Conditions
Post Operative Cognitive Dysfunction
Sponsor
The Geelong Hospital
Enrollment
370
Status
Recruiting
Last Updated
6 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
April 15, 2014
End Date
TBD
Last Updated
6 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
The Geelong Hospital

Eligibility Criteria

Inclusion Criteria

  • •Patients above the age of 60 years undergoing major elective non cardiac surgery, defined as surgery expected to last at least 1 hour in duration and requiring admission to hospital.

Exclusion Criteria

  • •Participants will be ineligible to take part if they;
  • •\* Have known contraindications to NAC including allergies and concomitant nitrate therapy
  • •\* Are unable to comply with the requirements of informed consent or the study protocol
  • •\* Are already taking NAC
  • •\* Require subsequent procedures necessitating general anaesthesia prior to completion of testing procedures
  • •\* Are undergoing carotid endarterectomy, due to the high incidence of perioperative cerebrovascular accidents
  • •\* Experience major perioperative morbidity, or mortality, that precludes them from completing post\-operative cognitive testing within the prescribed time frame.

Outcomes

Primary Outcomes

Not specified

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