Treatment using N-acetyl cysteine (Injection) to reduce occurrence of muscle weakness and death in patients admitted with organophosphate (OP) pesticide poisoning.
Phase 2
- Conditions
- Health Condition 1: T600- Toxic effect of organophosphate and carbamate insecticides
- Registration Number
- CTRI/2020/09/028060
- Lead Sponsor
- Christian medical college Vellore
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Inclusion criteria
The diagnosis of Organophosphate Poisoning made on the basis of typical clinical toxidrome of cholinergic and nicotinic manifestations and
Reliable identification of the compound ingested on the basis of the container brought by the patients attendants or
A subsequent confirmation of significant exposure based on suppression of serum pseudocholinesterase levels to less than 1000 U per L
Exclusion Criteria
Presentation more than 48 hours of having consumed the organophosphate compound (late presenters)
Those suspected to have a mixed or polysubstance overdose (other than ethanol and pyrethroid).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome measure was incidence of Intermediate Syndrome (IMS).Timepoint: At baseline, day 3 day 5 and discharge
- Secondary Outcome Measures
Name Time Method