NL-OMON31618尚未招募不适用
A randomized double-blind study of N-Acetylcysteine vs. placebo to Prevent Neurotoxicity induced by Platinum containing chemotherapy in patients treated for (Non)Small Cell Lung Cancer and Malignant Mesothelioma. - NAC-PNP-study
Rijnstate Ziekenhuis0 个研究点目标入组 50 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •-diagnose is histologically or cytologically proven (NSCLC,SCLC), malignant mesothelioma (histologically)
- •-at least 4 cycles of cisplatin are planned
- •-adequate renal function (creatinine clearance as calculated by Cockroft-Gault method > 60 ml/min)
- •- Karnofski performance score > 60 %
- •-written informed consent
- •-patient must be able to comply with study measurements i.e. hospital visits for EMG and QoL assessments
- •-age >= 18 years
排除标准
- •-patients with pre-existing neuropathy
- •-patients not willing to stop earlier prescribed NAC
- •-patients not willing to stop vitamins E and A above daily advisory dosage
- •-uncontrolled metastasis in the central or peripheral nervous system
研究者
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