to check if dentin can be used as a bone graft instead of commercially available bone grafts.

Phase 3

Completed

• Conditions: Intraossesous Vertical Defect

• Registration Number: CTRI/2017/02/007942
• Lead Sponsor: DrDivya Raj

Brief Summary

Objective: The aim of the present study was to evaluate and compare the efficacy of Autogenous Demineralized Dentin (ADD) with nanocrystalline Hydroxyapatite (nHA) bone graft in intrabony periodontal defects.

Material and Methodology: Twenty-one patients with chronic periodontitis with a total of 57 intrabony defects were divided into two treatment groups. Group A (n=34) was treated with ADD, derived from a tooth indicated for extraction because of non-endodontic reasons and Group B (n=23) treated with nHA bone graft (SyboGrafâ„¢, Eurocare, India). Clinical parameters were recorded at baseline and six months and radiographic parameters recorded at baseline three months and six months.

Results: Both groups showed significant improvement of clinical and radiographic parameters from baseline to 6 months and on comparing the two groups both ADD and HA had similar treatment outcomes. Mean Probing Depth (PD) reduction from baseline to 6 months was 3.53 ± 0.95mm and 3.70 ± 1.03 mm with ADD and nHA respectively (p value = 0.764, NS), whereas the mean Probing Attachment Level (PAL) gain was 3.41 ± 1.64mm and 3.1 ±mm (p value = 0.445) respectively.  The radiographic defect fill also showed similar results (p value = 0.331) as the mean percentage 6 months post-op was 79.80% for ADD and 78.25% for nHA.

Conclusion: No adverse reaction or complication was seen in cases treated with ADD and clinically it showed comparable results with commercially available nHA. Moreover, radiographically areas of graft resorption and trabeculae formation were evident at some sites treated with ADD unlike sites treated with nHA. Therefore, ADD may be used as a bone graft substitute following histopathologic confirmation of bone formation.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-03-15
• Study Completion: 2018-10-15
• Last Update Posted: 2020-12-18

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 69

Inclusion Criteria

Chronic generalized periodontitis Clinical probing depth ≥ 5mm Radiographic presence of vertical defects Patient selected for autograft to have a tooth indicated for extraction.

Exclusion Criteria

• Patients with generalized aggressive periodontitis Suffering from any systemic disease Pregnancy or lactation Underwent periodontal surgery previously for the same Smokers or using other tobacco products For patients receiving dentin as autograft: Extracted tooth due to dental caries or periapical pathology.
• Endodontically treated tooth indicated for extraction.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improved GINGIVAL INDEX – ( Loe and Silness – 1963)	6 months
•PLAQUE INDEX – (Silness and Loe – 1964)	6 months
•Pocket probing depth	6 months
• Improved Clinical attachment level	6 months

Secondary Outcome Measures

Name	Time	Method
Radiographic eveidence of BONE FILL	(Will be calculated using standardized IOPA Radiograph using a grid in paralleling technique)

Trial Locations

Locations (1)

Manipal College of Dental Sciences; 🇮🇳 Udupi, KARNATAKA, India

Manipal College of Dental Sciences

🇮🇳Udupi, KARNATAKA, India

Dr Divya Raj

Principal investigator

7259573377

divyarajsinghrore@gmail.com