Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

Not Applicable

Completed

• Conditions: Headache; Migraine
• Interventions: Other: Carbon monoxide; Other: Placebo

• Registration Number: NCT02066558
• Lead Sponsor: Danish Headache Center

Brief Summary

In this study the investigators will research the hypothesis that the gas carbon monoxide induces headache and increases the blood flow velocity in the middle cerebral artery.

Detailed Description

To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.

With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.

Study Timeline

• Study Start: 2014-02
• Study First Submitted: 2014-02-17
• Study First Submitted QC: 2014-02-18
• Study First Posted: 2014-02-19
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-11
• Last Update Posted: 2015-02-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Healthy volunteers
• Aged 18-50
• 50-100 kg

Exclusion Criteria

• Tension type headache more than once/month
• Other primary headaches
• Daily medication except contraceptives
• Drug taken within 4 times the halflife for the specific drug except contraceptives
• Pregnant or lactating women
• Exposure to radiation within the last year
• Headache within the last 24 hours before start of trial
• Hypertension
• Hypotension
• Respiratory or cardiac disease
• Smoking
• Primary relatives with current or previous migraine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
carbon monoxide	Carbon monoxide	Inhalation of carbon monoxide up to a carboxyhemoglobin concentration of 12% and 22%.
placebo	Placebo	Atmospheric air

Primary Outcome Measures

Name	Time	Method
Headache scores	12 h	Comparison between carbon monoxide and placebo (atmospheric air)

Secondary Outcome Measures

Name	Time	Method
Blood flow velocity	0-180 min after inhalation	Carbon monoxide induced changes in blood flow velocity in the middle cerebral artery before and after inhalation.
Artery circumference	0-180 min	Carbon monoxide induced changes in the superficial temporal artery and the radial artery before and after inhalation.
Facial blood flow	0-180 min	Carbon monoxide induced changes in facial blood flow before and after inhalation.

Trial Locations

Locations (1)

Danish Headache Center; 🇩🇰 Glostrup, Denmark