Carbon Monoxide Headache Triggering Properties as Well as Effects on the Brain's Vessels and Blood Flow
Not Applicable
Completed
- Conditions
- Headache Disorders
- Interventions
- Other: Carbon monoxide
- Registration Number
- NCT03385174
- Lead Sponsor
- Danish Headache Center
- Brief Summary
Studying Carbon monoxide effects on brain vessels in healthy volunteers with magnetic resonance imaging.
- Detailed Description
In this study we will systematically investigate the headache-releasing properties of carbon monoxide as well as measure the effect of carbon monoxide on mean blood flow rate in the brain's large vessel with magnetic resonance imaging. These studies are important for understanding and further investigating the carbon monoxide's headache-releasing effect in healthy subjects.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
- Healthy volunteers
- Aged 18-50
- 50-100 kg
Exclusion Criteria
- Tension type headache more than 5 dage /month
- Other primary headaches
- Daily medication except contraceptives
- Drug taken within 4 times the halflife for the specific drug except contraceptives
- Pregnant or lactating women
- Exposure to radiation within the last year
- Headache within the last 24 hours before start of trial
- Hypertension
- Hypotension
- Respiratory or cardiac disease
- Smoking
- Primary relatives with current or previous migraine
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Carbon monoxide Carbon monoxide Each participant receives CO inhalation
- Primary Outcome Measures
Name Time Method Changes in brain blood vessels diameters after a short CO inhalation 30 minutes To investigate changes in the circumference of intra- and extracerebral blood vessels after inhalation of carbon monoxide using magnetic resonance angiography (MRA).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Danish Headache Center
🇩🇰Glostrup, Denmark