Carbon Monoxide Migraine-inducing Effects in Patients With Migraine Without Aura.
Not Applicable
Completed
- Conditions
- Headache, Migraine
- Interventions
- Other: AIROther: Carbon monoxide
- Registration Number
- NCT03075020
- Lead Sponsor
- Danish Headache Center
- Brief Summary
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.
- Detailed Description
To investigate headache score and accompanying symptoms during and after inhalation of carbon monoxide.
With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- Healthy volunteers
- Aged 18-50
- 50-100 kg
Exclusion Criteria
- Tension type headache more than once/month
- Other primary headaches
- Daily medication except contraceptives
- Drug taken within 4 times the halflife for the specific drug except contraceptives
- Pregnant or lactating women
- Exposure to radiation within the last year
- Headache within the last 24 hours before start of trial
- Hypertension
- Hypotension
- Respiratory or cardiac disease
- Smoking
- Primary relatives with current or previous migraine
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Air AIR - Active carbon monoxide Carbon monoxide Inhalation of carbon monoxide up to a carboxyhemoglobin concentration 22%
- Primary Outcome Measures
Name Time Method Headache scores, 12 hours 12 hours Comparison between carbon monoxide and placebo (atmospheric air)
- Secondary Outcome Measures
Name Time Method Facial blood flow [ Time Frame: 0-180 min ] Carbon monoxide induced changes in facial blood flow before and after inhalation.
Trial Locations
- Locations (1)
Danish Headache Center
🇩🇰Glostrup, Denmark