The role of inflammatory mediators (platelet activity,the number and origin of micro particles and levels of mitochondrial DNA) in patient with acute renal transplant rejection.

Completed

• Conditions: acute renal transplant injury; renal inflammation; 10003816; 10029149

• Registration Number: NL-OMON41402
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 65

Inclusion Criteria

Renal transplant recipients from heart beating, non-heart-beating donors and living donors.
Patients and healthy volunteers have to sign the informed consent form.

Exclusion Criteria

-

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main parameter of this study is the presence and activity of inflammatory<br /><br>mediators, platelet activity (measured as P-selectin positive platelets), the<br /><br>origin and numbers of micro particles, and levels of circulating (plasma) and<br /><br>local (urinary) mtDNA). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Concentrations of proinflammatory cytokines and chemokines in plasma and urine<br /><br>(TNF-alpha, IL-1beta, IL-6 and IL-8) and acute tubular injury markers in urine<br /><br>(KIM-1 and NGAL). </p><br>