The role of Substance P and inflammatory mediators in underlying mechanism of traditional Malay massage (urut Melayu) in reducing muscle stiffness and inflammation for stroke rehabilitation.

Not Applicable

• Conditions: Stroke; Stroke - Ischaemic; Stroke - Haemorrhagic

• Registration Number: ACTRN12620000471987
• Lead Sponsor: Ministry of Education

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-04-14
• Last Update Posted: 20 April 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

1. Subacute and chronic stroke
3. National Institute of Health Stroke (NIH) scores between 5 to 25 points.
4. Functional Ambulation Category (FAC) of 4 and 5.
5. The Body Mass Index (BMI) is 18.5 - 24.9 kg/m (normal weight)
6. Patient are able to follow command and instructions.
7. Patients are willing to participate in this study.

Exclusion Criteria

1. Patients are unable to follow command and instructions.
2. Patients having nerve compression or spinal disorder (eg. Spondylolisthesis, Herniated nucleus pulposus)
3. Infectious diseases such as AIDS/HIV, Tuberculosis, Bronchitis, Pneumonia.
4. Acute infections and inflammation such as gout, Rheumatoid Arthritis, Osteoarthritis, Appendicitis .
5. Vascular diseases such as Aneurysm, Varicose Vein, Venous Thrombosis, Hypertension.
6. Any type of post-surgery.
7. Loss of vision.
8. Cognitive, emotional and behavioral problem such as Dyslexia, Schizophrenia.
9. Skin problem or sensitive with any topical cream or oil massage.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The substance P level (pg/mL) in blood samples. These samples will be analysed using Human Substance P enzyme-linked immunosorbent assay (ELISA) kit.[The blood samples will be taken before (pre-treatment) and immediately after treatment (post-treatment).<br>];The substance P level (pg/mL) in saliva samples. These samples will be analysed using Human Substance P enzyme-linked immunosorbent assay (ELISA) kit.[The saliva samples will be taken before (pre-treatment) and immediately after treatment (post-treatment).<br>]