The moderating role of inflammatory and serotonergic genes on cardiovascularstress reactivity in recently bereaved adults
- Conditions
- Effects of grief on the cardiovascular system
Recruitment & Eligibility
- Status
- Recruiting stopped after recruiting started
- Sex
- All
- Target Recruitment
- 67
Inclusion Criteria
recently bereaved (defined as 6-24Month).
adults (aged 50-70 years), postmenopausal.
free of major medical illnesses (e.g., cancer, current major psychiatric disorder such as Major Depressive Disorder, substance dependence).
currently not using:
- Immunosuppressive medication
- Anticholinergic medication
Exclusion Criteria
IL-6 levels larger 2 standard deviations above the mean, if there is self-reported illness two weeks prior to experimental assessments.
Medical non-compliance in context with chronic diseases (e.g. diabetes, rheumatoid arthritis).
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary endpoint: change in vagal mediated cardiac autonomic activity as measured using Root Mean Square of Successive Differences (RMSSD) and High-Frequency Component (HFpower), moderated by 5-HTTLPR (5-Hydroxytryptamin transporter linked polymorphic region).
- Secondary Outcome Measures
Name Time Method Plasma levels of Interleukin 6 (IL-6) - (moderated by IL-6 -174 & IL-6 -572, 5-HTTLPR (5-Hydroxytryptamin transporter linked polymorphic region))<br>