Relation betwEen abdominal aorta and carotid artery responses to SymPathetic stimulatiON uSing duplEx ultrasound

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

- Young healthy group: Male or female between the age of 18 and 40 years
old;
- Older healthy group: Male or female, which are age-/sex-matched with the
AAA patients group;
- AAA patients group: Male or female with an abdominal aortic aneurysm who
is still under surveillance, with a diameter between 3.0 and 5.0 cm and at
least 18 years old. These patients may participate in the 1-2-3 Trial, which is
a similar approved investigation by CMO region Arnhem-Nijmegen with
registration number 2019-5216.
- Informed consent form understood and signed;

Exclusion Criteria

- Psychiatric or other conditions that may interfere with the study;
- Participating in another clinical study, interfering on outcomes;
- With regard to the necessary quality of the ultrasound images, BMI * 30
kg/m2;
- Increased risk for coronary spasms (score Rose-questionnaire * 2);
- Presence of Raynaud*s phenomenon, Marfan syndrome, chronic pain
syndrome at upper extremity(s), presence of an AV fistula or shunt, open wounds
to the upper extremity(s), and/or scleroderma associated with placing the hand
in ice water;
- Recent (< 3 months) presence of angina pectoris, myocardial infarction,
cerebral infarction, and/or heart failure, or PAD treatment.
- Healthy groups:
o Systolic blood pressure >140 mmHg and/or diastolic blood pressure >90 mmHg
o Cardiovascular history
o Antihypertensive medication

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint is the results of the CPT of the abdominal aorta and<br /><br>the carotid artery for each participant; this can be either a vasodilation or<br /><br>vasoconstriction in response to the sympathetic stimulus.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters include:<br /><br>- Other CPT results of the abdominal aorta and the carotid artery<br /><br>o Magnitude and timing of the blood flow and perfusion response<br /><br>o Blood pressure and heart rate response<br /><br>- Age</p><br>