Cardiovascular RiskprofilE: IMaging And Gender-specific disOrders
Completed
- Conditions
- reproductieve aandoeningenCardiovascular diseases1001108210003216
- Registration Number
- NL-OMON47070
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 600
Inclusion Criteria
* Age 40 years or older
* Female
* Capable and willing to provide informed consent.
* Fulfil criteria for diagnosis of hypertensive pregnancy disorders OR fulfil criteria for diagnosis PCOS OR fulfil criteria for diagnosis POI
Exclusion Criteria
* Patients with insufficient mastery of Dutch or English.
* Patients with any serious illness that can compromise study participation.
* Patient who have had a myocardial infarction.
* Patients with high risk for contrast nephropathy (renal function disorder).
* Patients with a history of allergy to iodinated contrast medium.
* Patients who are currently pregnant.;Healthy controls: history of hypertensive pregnancy disorders
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Assessment of coronary artery disease (plaque and stenosis) by CCT (both CACS<br /><br>and CCTA) and carotid siphon CT in patients with a reproductive disorder and<br /><br>who are at least 40 years old to improve diagnostic evaluation of<br /><br>cardiovascular risk factors.</p><br>
- Secondary Outcome Measures
Name Time Method <p>To compare imaging markers of cardiovascular disease (plaque and stenosis<br /><br>measured by CCT) with standardized vascular screening.<br /><br>To construct and improve prediction models for the onset of CVD in these<br /><br>patients.</p><br>