Cardiovasculair RisicoprofiEl: IMAGing en reprOductieve aandoeninge
- Conditions
- Reproductive disorders, polycystic ovary syndrome (PCOS), preeclampsia, primary ovarian insufficiency, migraine, venous thromboembolism, cardiovascular disease, risk prediction, coronary computed tomography (CCT) <br />Reproductieve aandoeningen, polycysteus ovariumsyndroom (PCOS), pre-eclampsie, primaire ovariële insufficiëntie, migraine, veneus tromboembolisme, cardiovasculaire aandoeningen, risico predictie, coronaire computertomografie (CCT)
- Registration Number
- NL-OMON22481
- Lead Sponsor
- niversity Medical Center Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 600
Inclusion Criteria
• Age above 45 years old
• Female
Exclusion Criteria
• Patients with insufficient mastery of Dutch.
• Patients with any serious illness that can compromise study participation.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method • Coronary plaque measured by Coronary Computed Tomography (CCT) including both non-contrast coronary calcium scoring (CACS) and contrast enhanced coronary CT (CCTA).<br>• Coronary artery stenosis measured by CCTA. <br>• Biomarkers parameters: plasma CECs, extracellular vesicle protein- and miRNA-concentration, and plasma gene expression profiles in circulating endothelial cells. Numbers, subtype distribution and epigenetic profiles of inflammatory genes of circulating cells.<br>• Vascular measurements (arterial stiffness)
- Secondary Outcome Measures
Name Time Method Traditional CVD risk factors (information collected as part of regular cardiovascular screening).