Dexmedetomidine versus Haloperidol efficacy on intra-abdominal pressure, inflammatory response and duration of mechanical ventilation in patients with abdominal sepsis: Comparative Study Controlled by Propofol
Not Applicable
- Conditions
- Anaesthesia
- Registration Number
- PACTR202305682901262
- Lead Sponsor
- sherif kamal hafez arafa
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
1-adult patients = 18 years old till 70 years old
2- diagnosed with intestinal obstruction or abdominal sepsis,
3- who underwent abdominal surgery to control the source of infection and required postoperative sedation for mechanical ventilation
4- SOFA score = 2 points due to intra-abdominal infection.
Exclusion Criteria
1- patients less than 18 years and more than 70
2- Ischemic heart diseases and heart failure
3-patient with cerebrovascular event
4- patients with neurological deficit
5-pateints with source of infection other than abdominal infection
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method to investigate the effects of sedation of patients with abdominal sepsis with dexmedetomidine versus sedation with propofol and effects on inflammatory mediators as IL-6, IL-8 and serum lactate level
- Secondary Outcome Measures
Name Time Method Intra-abdominal hypertension (IAH) ,icu hospital stay and mortality