The impact of tissue eosinophilia and the extent of sinus surgery on its clinical characteristics and therapeutic outcomes of patients with Chronic Rhinosinusitis

Recruiting

• Conditions: Chronic rhinosinusitis; Eosinophilic chronic rhinosinusitis; Non-eosinophilic chronic rhinosinusitis; Tissue eosinophil; Extent of Sinus surgery; sinus surgery; Symptoms VAS; SNOT-22; Lund -Kennedy endoscopy score; Lund-Mackay CT scan score

• Registration Number: TCTR20240316001
• Lead Sponsor: Ratchadapisek Research Funds, Faculty of Medicine, Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-03-16
• Study Completion: 2024-05-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. Age above 18 years
2. Chronic rhinosinusitis following diagnostic criteria of EPOS2020
3. Failed to improve from a minimum of 6-week period medical therapy requiring ESS
4. All patients underwent ESS
5. Able to give informed consent

Exclusion Criteria

- Unilateral sinus disease: fungal ball, odontogenic-related disease, allergic fungal sinusitis, neoplasm associated with sinus disease
- Systematic disease associated with sinus: cystic fibrosis, Churg-Strauss, immunodeficiency, Wegener granulomatosis, autoimmune disease
- Undertaking immunosuppressive medicines
- Pregnancy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
SNOT-22 1 year linear regression

Secondary Outcome Measures

Name	Time	Method
VAS symptoms, LK score, LM CT score, Kennedy osteitis score, Blood eosinophil count, Comorbidities: Allergic rhinitis, Asthma, NSAID-exacerbated respiratory disease (NERD) 1 year spearman rank order coefficient, logistic regression ,