The utility of an additional pacing wire on the left side of the heart in patients who are undergoing pacemaker implantation for heart failure i.e. Cardiac Resynchronization Therapy
Not Applicable
- Conditions
- Health Condition 1: I502- Systolic (congestive) heart failure
- Registration Number
- CTRI/2022/09/045773
- Lead Sponsor
- Dr Chinmay Parale
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age more than 18 years
2.Non ischemic cardiomyopathy (Cardiomyopathy with normal coronaries on an angiogram)
3.NYHA class II-IV symptoms (Ambulatory class IV) 4.LVEF less than or equal to 35 percent
5.Left bundle branch block with QRS duration more than 130 msec
6.Sinus rhythm
7.On optimal medical management for heart failure for at least three months
8.Successful implantation of the coronary sinus (CS) lead and left bundle branch area (LBA) lead
Exclusion Criteria
1.Patients with non-ambulatory class IV heart failure and hypotension requiring persistent inotropes
2.Patients with a serum creatinine level of more than 3.0 mg/dl
3.Patients with a primary mitral valvular pathology causing moderate or severe mitral regurgitation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method QRS width and LV ejection fraction (LVEF) <br/ ><br>Timepoint: 2 days and 6 months respectively <br/ ><br>
- Secondary Outcome Measures
Name Time Method ECG parameters (QRS width, QTc, QT dispersion, T peak to T end interval)Timepoint: 6 months;Echocardiographic parameters (LV Ejection fraction, LV end systolic volume, global longitudinal and circumferential strain, degree of mitral regurgitation)Timepoint: 6 months;Echocardiographic parameters (LV pre-ejection interval , Interventricular mechanical delay, TVI, dP/dt, LVEF)Timepoint: 2 days;Repolarization parameters (QTc, QT dispersion, T peak to T end interval) on ECGTimepoint: 2 days;Responder rateTimepoint: 6 months