Continous Quadratus Lumborum Block for Hepatic Surgery With Right Subcostal Incision

Not Applicable

Terminated

• Conditions: Hepatectomy; Analgesia; Nerve Block
• Interventions: Procedure: Continous QLB (quadratus lumborum block); Device: Philip CX50 Ultrasound Scanner; Drug: Ropivacaine; Drug: Morphine given as IPCA

• Registration Number: NCT02914015
• Lead Sponsor: Cui Xulei

Brief Summary

This prospective, randomized study, control study aims to compare the analgesic effect, opioids consumption, quality of recovery, length of hospital stay and et al. between unilateral continuous quadratus lumborum block (QLB) and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-09-22
• Study First Submitted QC: 2016-09-23
• Study First Posted: 2016-09-26
• Study Start: 2018-08-01
• Primary Completion: 2019-05-29
• Study Completion: 2019-05-29
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-02
• Last Update Posted: 2019-09-04

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Age 18-70 yrs
• American Society of Anesthesiologists physical statusⅠ-Ⅲ
• Undergo hepatectomy with right J-shape subcostal incision
• Informed consent

Exclusion Criteria

• A known allergy to the drugs being used
• Coagulopathy, on anticoagulants
• Analgesics intake, history of substance abuse
• Participating in the investigation of another experimental agent
• Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Continuous QLB+postoperative IPCA	Morphine given as IPCA	Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
Continuous QLB+postoperative IPCA	Philip CX50 Ultrasound Scanner	Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
Continuous QLB+postoperative IPCA	Continous QLB (quadratus lumborum block)	Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)
IPCA	Morphine given as IPCA	Postoperative IPCA (intravenous patient control analgesia) is given alone
Continuous QLB+postoperative IPCA	Ropivacaine	Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia)

Primary Outcome Measures

Name	Time	Method
Cumulative morphine consumption	at 24 postoperative hours

Secondary Outcome Measures

Name	Time	Method
Nausea and Vomiting score	At 0, 2,4, 8, 12, 24 and 48 hours after the surgery
Ambulation time	within the 7 days after surgery
Patient satisfaction with anesthesia	48 hours after surgery	use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia
Postoperative hospital length of stay	Up to 6 weeks
Quality of recovery	3 days and 7 days after surgery	use the self-assessment 11 item QoR scale to assess the patient's recovery quality
Pruritus score	At 0, 2,4, 8, 12, 24 and 48 hours after the surgery
The pain scores determined by the numeric rating scale (NRS, 0-10)	At 0, 2,4, 8, 12, 24 ,48,72 hours and 7 day after the surgery
Time of recovery of bowl movement	within the 7 days after surgery

Trial Locations

Locations (1)

Xulei CUI; 🇨🇳 Beijing, Beijing, China