TQLB for Postoperative Pain After Laparoscopic Partial Nephrectomy

Not Applicable

Completed

• Conditions: Laparoscopic Renal Surgery; Pain Management; Nerve Block
• Interventions: Drug: Morphine given as IPCA(intravenous patient controlled analgesia); Procedure: single-injection TQLB(transmuscular quadratus lumborum block)

• Registration Number: NCT03982784
• Lead Sponsor: Cui Xulei

Brief Summary

This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay，et al. between single-injection QLB(quadratus lumborum block)+ intravenous patient-controlled analgesia (IPCA) and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing laparoscopic partial nephrectomy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-06-04
• Study First Submitted QC: 2019-06-09
• Study Start: 2019-06-10
• Study First Posted: 2019-06-12
• Status Verified: 2019-11
• Primary Completion: 2019-11-01
• Study Completion: 2019-11-10
• Last Update Submitted: 2019-11-10
• Last Update Posted: 2019-11-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

• A known allergy to the drugs being used
• Coagulopathy, on anticoagulants
• Analgesics intake, history of substance abuse
• Participating in the investigation of another experimental agent
• Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Morphine given as IPCA(intravenous patient controlled analgesia)	postoperative IPCA is given alone
single-injection TQLB(transmuscular quadratus lumborum block)	single-injection TQLB(transmuscular quadratus lumborum block)	Single-injection of TQLB is given preoperatively + postoperative IPCA(intravenous patient controlled analgesia)
single-injection TQLB(transmuscular quadratus lumborum block)	Morphine given as IPCA(intravenous patient controlled analgesia)	Single-injection of TQLB is given preoperatively + postoperative IPCA(intravenous patient controlled analgesia)

Primary Outcome Measures

Name	Time	Method
cumulative morphine consumption 8 hours after surgery	at the 8 hours after surgery

Secondary Outcome Measures

Name	Time	Method
postoperative length of hospital stay	within 2 weeks after the surgery	time to patient's discharge
cumulative morphine consumption at other time points after surgery	at 0, 2, 4, 12, 24 and 48 hours after surgery
episodes of nausea and vomiting	within 24 hours after the surgery
quality of recovery evaluated by the self-assessment 15-item quality of recovery (QoR) scale	at 72 hours and 120 hours after the sugery	QoR is a 15-item questionnaire which will score on a scale of 0-10 pertaining to patient's comfort, support system, pain, well-being, and ability to carry out daily activities, where 0 indicates none of the time and 10 indicates all of the time
ambulation time	within the 5 days after surgery	time from the end of the surgery to the first time to out-of-bed activity
The pain scores(at rest or on activity) determined by the numeric rating scale (NRS, 0-10)	at 0, 2, 4, 8,12, 24, 48 and 72 hours after surgery	NRS is an internationally recognized pain scale with 11 points ranging from 0 to 10 points, with 0 defined as no pain and 10 defined as the worst pain imaginable.
time of recovery of bowl movement	within the 5 days after surgery	time from the end of the surgery to the first time of bowl movement
patient satisfaction with anesthesia	at 48 hours after surgery	Patient satisfaction with anesthesia was assessed using a 5-point scale (5: very satisfied; 4: satisfied; 3: neither satisfied nor dissatisfied; 2: dissatisfied; 1: very dissatisfied)

Trial Locations

Locations (1)

Cui Xulei; 🇨🇳 Beijing, Beijing, China