Thoracic Paravertebral Block : Effect on Acute Pain and Chronic Pain of Hepatectomy With Right J-shape Subcostal Incision

Not Applicable

Completed

• Conditions: Nerve Block; Hepatectomy; Analgesia
• Interventions: Procedure: single-injection TPVB + continuous TPVB; Device: Philip CX50 Ultrasound Scanner; Device: PAJUNK Contiplex S Catheter; Drug: single dose ropivacaine; Drug: continuously infusion of ropivacaine; Drug: Morphine given as IPCA

• Registration Number: NCT02817321
• Lead Sponsor: Cui Xulei

Brief Summary

This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay and incidence of chronic pain,et al. single-injection TPVB +continuous(pulsatile infusion) TPVB and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-06-22
• Study First Submitted QC: 2016-06-25
• Study First Posted: 2016-06-29
• Study Start: 2016-11
• Primary Completion: 2017-10-31
• Study Completion: 2018-11
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-06
• Last Update Posted: 2019-01-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

• Age 18-70 yrs
• American Society of Anesthesiologists physical statusⅠ-Ⅲ
• Undergo hepatectomy with J-shape subcostal incision
• Informed consent

Exclusion Criteria

• A known allergy to the drugs being used
• Coagulopathy, on anticoagulants
• Analgesics intake, history of substance abuse
• Participating in the investigation of another experimental agent
• Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Single-injection TPVB +continuous TPVB	Morphine given as IPCA	Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Single-injection TPVB +continuous TPVB	Philip CX50 Ultrasound Scanner	Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Single-injection TPVB +continuous TPVB	single-injection TPVB + continuous TPVB	Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Single-injection TPVB +continuous TPVB	PAJUNK Contiplex S Catheter	Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Single-injection TPVB +continuous TPVB	continuously infusion of ropivacaine	Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
Single-injection TPVB +continuous TPVB	single dose ropivacaine	Single-injection of TPVB is given preoperatively followed with continuous infusion+ postoperative IPCA.
IPCA	Morphine given as IPCA	postoperative IPCA is given alone

Primary Outcome Measures

Name	Time	Method
cumulative morphine consumption	within 48 postoperative hours

Secondary Outcome Measures

Name	Time	Method
The pain scores determined by the numeric rating scale (NRS, 0-10)	At 0, 2,4, 8, 12, 24 ,48,72hours and 7day after the surgery
nausea and vomiting score	At 0, 2,4, 8, 12, 24 and 48hours after the surgery
ambulation time	within the 7 days after surgery
patient satisfaction with anesthesia	48 hours after surgery	use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia
pruritus score	At 0, 2,4, 8, 12, 24 and 48hours after the surgery
time of recovery of bowl movement	within the 7 days after surgery
Postoperative hospital length of stay	Up to 4 weeks
data collection of chronic pain	at 3,6,12 months after surgery	Patients undergo a telephone interview with a questionnaire at 3, 6 and 12 months after surgery, the incidence and severity of chronic pain is recorded.

Trial Locations

Locations (1)

Xulei CUI; 🇨🇳 Beijing, Beijing, China