Transmuscular Quadratus Lumborum Block for Postoperative Pain After Laparoscopic Adrenalectomy

Not Applicable

Completed

• Conditions: Pain Management; Nerve Block; Laparoscopic Adrenalectomy
• Interventions: Procedure: single-injection QLB(quadratus lumborum block); Procedure: Placebo Control

• Registration Number: NCT03942237
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

This prospective, randomized control study aims to compare the analgesic effect, satisfaction with anesthesia and analgesia between single-injection QLB (quadratus lumborum block)+general anesthesia (GA) and general anesthesia (GA) alone in patients undergoing laparoscopic adrenalectomy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-05-07
• Study First Submitted QC: 2019-05-07
• Study First Posted: 2019-05-08
• Study Start: 2019-05-10
• Primary Completion: 2019-08-28
• Study Completion: 2019-09-02
• Status Verified: 2019-12
• Last Update Submitted: 2019-12-31
• Last Update Posted: 2020-01-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• Age 18-70 yrs
• American Society of Anesthesiologists physical statusⅠ-Ⅲ
• Undergo laparoscopic adrenalectomy
• Informed consent

Exclusion Criteria

• a known allergy to the medications being used for anesthesia
• coagulopathy or on anticoagulants
• chronic opioid therapy or history of substance abuse
• participating in another RCT
• inability to properly describe postoperative pain to investigators (e.g., language barrier, neuropsychiatric disorder).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
single-injection QLB (quadratus lumborum block)	single-injection QLB(quadratus lumborum block)	Single-injection of QLB with local anesthetic is given preoperatively
Placebo control	Placebo Control	Single-injection of QLB with NS is given preoperatively

Primary Outcome Measures

Name	Time	Method
the NRS pain scores on activity 12-hours after surgery	12-hours after surgery	The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool

Secondary Outcome Measures

Name	Time	Method
the pain scores at rest determined by the numeric rating scale (NRS, 0-10)	At 2,4, 8, 12, 24 ,48,72 hours after the surgery	The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool
time of recovery of bowel movement	within 5 days after surgery	defined as the time to first flatus
the NRS pain scores on activity after surgery	At 2,4, 8, 24 ,48,72 hours after the surgery	The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool
incidence of postoperative nausea and vomiting (PONV)	within 24 postoperative hours
patient's satisfaction of anesthesia and analgesia	48 hours after surgery	use the Chinese version of Bauer questionnaire to assess the patient satisfaction of anesthesia
ambulation time	within 5 days after surgery
postoperative length of hospital stay	up to 2 weeks after surgery

Trial Locations

Locations (1)

Peking Union Medical College Hospital; 🇨🇳 Beijing, China