QLB Versus PVB for Acute Pain and Quality of Recovery After Laparoscopic Partial Nephrectomy

Not Applicable

Completed

• Conditions: Nerve Block, Nephrectomy, Analgesia
• Interventions: Procedure: preoperative single-shot TMQLB; Procedure: preoperative single-shot TPVB; Drug: patient controlled intravenous analgesia(PCIA)

• Registration Number: NCT03975296
• Lead Sponsor: Cui Xulei

Brief Summary

This trial is a prospective, randomized, single-center, open-label, parallel-arm, blinded-analysis trial, the objective of which is to evaluate the effect of transmuscular quadratus lumborum block (TMQLB) in the pain relief and quality of recovery in laparoscopic partial nephrectomy compared with thoracic paravertebral block (TPVB).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-06-02
• Study First Submitted QC: 2019-06-03
• Study First Posted: 2019-06-05
• Study Start: 2019-06-10
• Status Verified: 2020-03
• Primary Completion: 2021-01-01
• Study Completion: 2021-01-11
• Last Update Submitted: 2021-07-25
• Last Update Posted: 2021-07-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Age 18-70 yrs American Society of Anesthesiologists physical statusⅠ-Ⅲ Undergo laparoscopic nephrectomy Informed consent

Exclusion Criteria

A known allergy to the drugs being used Coagulopathy, on anticoagulants Analgesics intake, history of substance abuse Participating in the investigation of another experimental agent Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TMQLB group	preoperative single-shot TMQLB	-
TMQLB group	patient controlled intravenous analgesia(PCIA)	-
TPVB group	preoperative single-shot TPVB	-
TPVB group	patient controlled intravenous analgesia(PCIA)	-

Primary Outcome Measures

Name	Time	Method
cumulative morphine consumption	within 48 postoperative hours

Secondary Outcome Measures

Name	Time	Method
nausea and vomiting episodes	within 24 hours after the surgery]
time of recovery of bowl movement	within the 5 days after surgery
The pain scores determined by the numeric rating scale (NRS, 0-10)	within 48 postoperative hours	NRS is an internationally recognized pain scale with 11 points ranging from 0 to 10 points, with 0 defined as no pain and 10 defined as the worst pain imaginable.
dermatomal distribution of sensory reduction	30 min after the block	Thirty minutes after the block, the bilateral dermatomal sensory blocks for the anterior abdomen (between the anterior axillary and mid-clavicular lines) and thigh were assessed with the pinprick method. A reduce in pinprick sensation relative to the unblocked side was interpreted as an effective block.
quality of recovery evaluated by the self-assessment 15-item quality of recovery (QoR) scale	at 3 days and 5 days after the sugery	QoR is a 15-item questionnaire which will score on a scale of 0-10 pertaining to patient's comfort, support system, pain, well-being, and ability to carry out daily activities, where 0 indicates none of the time and 10 indicates all of the time
postoperative length of hospital stay	within 2 weeks after the surgery	time to patient's discharge
patient satisfaction with anesthesia	48 hours after surgery	use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia
ambulation time	within the 5 days after surgery	time from the end of the surgery to the first time to out-of-bed activity

Trial Locations

Locations (1)

Peking Union Medical College Hospital; 🇨🇳 Beijing, China