"Comparison of intravenous versus intranasal dexmedetomidineon attenuation of haemodynamic responses to laryngoscopy and endotrachealintubation: A randomized double blind interventional study at SMS MedicalCollege, Jaipur during 2021-2023"
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Heart Rate
研究概览
简要总结
Laryngoscopy and endotracheal intubation are associated with various haemodynamic changes due to sympathetic stimulation and to attenuate these response is a major challenge for anaesthesiologist. The satisfactory role of preoperative dexmedetomidine for attenuation of stress response is well established therefore in present study , we compare the efficacy of intranasal dexmedetomidine on stress response.We hypothesised that there is no significant difference between IV and IN routes of dexmedetomidine on attenuation of stress response.The study was designed to test this hypothesis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient of ASA grade I and II.
- •Patient undergoing elective surgery (Duration 60-70 minutes).
排除标准
- •1.History of allergy to dexmedetomidine 2.History of hypertension ,CAD,renal and hepatic dysfunctional
- •Patient with intranasal pathology like nasal polyp,ulcers and deviated septum.
- •4.Patient not willing to participate in the study.
- •5.Patient with cardiac and respiratory illness.
结局指标
主要结局
Heart Rate
时间窗: Baseline,after loading dose then every 10min interval till 40 min,at the time of induction ,every 1min till 5 minutes after induction ,7 min after intubation,every 10 min after intubation thereafter upto 60 minutes
次要结局
- Systolic BP,Diastolic BP and Mean Arterial Pressure(Baseline,after loading dose then every 10min interval till 40 min,at the time of induction ,every 1min till 5 minutes after induction ,7 min after intubation,every 10 min after intubation thereafter upto 60 minutes)
- Sedation Score(Baseline,after loading dose then every 10min interval till 40 min thereafter post operatively every 1 hour upto 4 hrs)
- Spo2(Baseline,after loading dose then every 10min interval till 40 min,at the time of induction ,every 1min till 5 minutes after induction ,7 min after intubation,every 10 min after intubation thereafter upto 60 minutes)