"Comparison of intravenous versus intranasal dexmedetomidine in reducing blood pressure and heart rate to laryngoscopy and endotrachealintubationâ€

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2022/04/042275
• Lead Sponsor: Department of Anaesthesiology SMS Medical college and attached hospitalsJaipur

Brief Summary

Laryngoscopy and endotracheal intubation are associated with various haemodynamic changes  due to sympathetic stimulation and to attenuate these response is a major challenge for anaesthesiologist. The satisfactory role of preoperative dexmedetomidine for attenuation of stress response is well established therefore in present study , we compare the efficacy of intranasal dexmedetomidine on stress response.We hypothesised that there is no significant difference between IV and IN routes of dexmedetomidine on attenuation of stress response.The study was designed to test this hypothesis.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-05-16
• Last Update Posted: 2022-07-04

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patient of ASA grade I and II.
• Patient undergoing elective surgery (Duration 60-70 minutes).

Exclusion Criteria

• 1.History of allergy to dexmedetomidine 2.History of hypertension ,CAD,renal and hepatic dysfunctional 3.
• Patient with intranasal pathology like nasal polyp,ulcers and deviated septum.
• 4.Patient not willing to participate in the study.
• 5.Patient with cardiac and respiratory illness.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Heart Rate	Baseline,after loading dose then every 10min interval till 40 min,at the time of induction ,every 1min till 5 minutes after induction ,7 min after intubation,every 10 min after intubation thereafter upto 60 minutes

Secondary Outcome Measures

Name	Time	Method
Systolic BP,Diastolic BP and Mean Arterial Pressure	Baseline,after loading dose then every 10min interval till 40 min,at the time of induction ,every 1min till 5 minutes after induction ,7 min after intubation,every 10 min after intubation thereafter upto 60 minutes
Sedation Score	Baseline,after loading dose then every 10min interval till 40 min thereafter post operatively every 1 hour upto 4 hrs
Spo2	Baseline,after loading dose then every 10min interval till 40 min,at the time of induction ,every 1min till 5 minutes after induction ,7 min after intubation,every 10 min after intubation thereafter upto 60 minutes

Trial Locations

Locations (1)

SMS Medical College and Attached Hospitals; 🇮🇳 Jaipur, RAJASTHAN, India

SMS Medical College and Attached Hospitals

🇮🇳Jaipur, RAJASTHAN, India

Dr Sumaila Naaz

Principal investigator

9058543688

sumailanaaz8@gmail.com