Glutamine-enriched enteral feeding in very low birth weight infants.

Completed

• Conditions: Gut adaptation and modulation of the immune response in very low birth weight infants.

• Registration Number: NL-OMON22969
• Lead Sponsor: Prof. W.P.F. FetterDepartment of PediatricsDivision of NeonatologyDe Boelelaan 11171081 HV AmsterdamNetherlands Tel: +31 20 4442413 Fax: +31 20 4443045 Email: w.fetter@vumc.nl

Brief Summary

1. Glutamine-enriched enteral nutrition in very low birth weight infants. Design of a double-blind randomised controlled trial. Anemone van den Berg, Ruurd M. van Elburg, Jos W.R. Twisk, Willem P.F. Fetter. Biomed Central Pediatrics 2004;4:17.<br> <br><br> 2. Glutamine-enriched enteral nutrition in very-low-birth-weight infants and effects on feeding tolerance and infectious morbidity: a randomized controlled trial. Anemone van den Berg, Ruurd M. van Elburg, Elisabeth A.M. Westerbeek, Jos W.R. Twisk, Willem P.F. Fetter. American Journal of Clinical Nutrition 2005;81:1397-1404.<br> <br><br> 3. A randomized controlled trial of enteral glutamine supplementation in very low birth weight infants: Plasma amino acid concentrations. Anemone van den Berg, Ruurd M. van Elburg, Tom Teerlink, Harrie N. Lafeber, Jos W.R. Twisk, Willem P.F. Fetter. Journal of Pediatric Gastroenterology and Nutrition 2005;41:66-71. <br> <br><br> 4. JPEN J Parenter Enteral Nutr. 2006 Sep-Oct;30(5):408-14.<br>

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 107

Inclusion Criteria

Infants with a gestational age < 32 weeks and/or a birth weight < 1500 grams.

Exclusion Criteria

Major chromosomal or congenital anomalies.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome of the study is time to full enteral feeding, defined as a feeding volume ¡Ý120 mL/kg/day.

Secondary Outcome Measures

Name	Time	Method
Furthermore, other parameters of feeding tolerance, infectious morbidity, and short-term outcome are evaluated. In addition to clinical outcome, intestinal permeability, faecal flora, plasma Th1/Th2 cytokine concentrations and plasma amino acid profiles are determined during the 30 day study period.