Aschistosoma Haematobiumspecific microRNAas a Tumor Marker for Early Diagnosis and Prognosis of Bilharzial Bladder Cancer in Eygpt

Not Applicable

Not yet recruiting

• Conditions: Bladder Cancer
• Interventions: Diagnostic Test: urinary micro RNA detection

• Registration Number: NCT05697224
• Lead Sponsor: Sohag University

Brief Summary

miRNAs have been detected in different bodily fluids, which suggests significant potential, such as their use as biomarkers in diagnostics and prognostics. Sha-mir-71a was abundantly found in the urine of patients with bladder cancer as compared to benign bladder cystitis associated with schistosomiasis . Additionally, this miRNA was more highly detected in urine samples from patients with bilharzial bladder cancer than bladder cancer not associated with bilharziasis (schistosomiasis), suggesting its specificity in the identification of bladder cancer associated with infection.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2023-01
• Study First Submitted: 2023-01-15
• Study First Submitted QC: 2023-01-15
• Last Update Submitted: 2023-01-15
• Study First Posted: 2023-01-25
• Last Update Posted: 2023-01-25
• Study Start: 2023-02-01
• Primary Completion: 2024-02-01
• Study Completion: 2024-05-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• urinary symptoms (hematuria, urinary retention, dysuria... etc.), who were planned to undergo cystoscopy for suspicion of bladder cancer (BC) or benign bilharzial cystitis (Bil), will be selected.

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Exclusion Criteria

• : In bladder cancer group Patients who have received chemotherapy, or with previously diagnosed other malignancy within the past 5 years.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
chronicurinary schistosomiasis	urinary micro RNA detection	-
bladder cancer diseased patients	urinary micro RNA detection	-

Primary Outcome Measures

Name	Time	Method
use micro RNAas adiagnostic test for early diagnosis of shistosomal bladder cancer	one year	Sha-mir-71a could be a biomarker with diagnostic and prognostic value