Gastric Volume After Ingestion of Carbohydrate Drink vs Water in Obese Volunteers

Not Applicable

Active, not recruiting

• Conditions: Obesity; Gastric Emptying
• Interventions: Procedure: Preopertive drink

• Registration Number: NCT05827029
• Lead Sponsor: Prince of Songkla University

Brief Summary

This randomized crossover study compares gastric residual volume after ingestion of carbohydrate drinks and water in obese volunteers. The main question\[s\] it aims to answer are:

* Is it safe for obese patients to shorten their fasting by allowing preoperative drinks?

* How long is the gastric emptying time in obese patients? Participants also will be evaluated the level of thirst/hungry and blood sugar.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-04
• Study Start: 2023-04-01
• Study First Submitted: 2023-04-09
• Study First Submitted QC: 2023-04-21
• Last Update Submitted: 2023-04-21
• Study First Posted: 2023-04-24
• Last Update Posted: 2023-04-24
• Primary Completion: 2023-05-31
• Study Completion: 2023-05-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Healthy volunteers
• Age 18 - 65 years old
• BMI ≥ 30 kg/m2
• NPO for at least 6 hours before the study

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Exclusion Criteria

• Diabetes Mellitus
• Chronic kidney disease or End-stage renal disease
• Use of any medication that affects gastric secretion or emptying (Histamine 2 receptor antagonist eg. Ranitidine/Proton pump inhibitor eg. Omeprazole/Acid neutralization eg. Aluminium hydroxide/Prokinetic eg. Domperidone) within the past 24 hours
• Gastroesophageal reflux disease
• Pregnancy
• History of upper gastrointestinal surgery
• In diet program or use appetite suppressant drug (eg. Liraglutide, Naltrexone, Phentermine, Diethylpropion) within the past 24 hours

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Water	Preopertive drink	-
Preoperative carbohydrate drink	Preopertive drink	-

Primary Outcome Measures

Name	Time	Method
gastric residual volume	baseline and every 30 minutes until 2 hours after drinking	changes in gastric residual volume during 2 hours after drinking

Secondary Outcome Measures

Name	Time	Method
POCT glucose	baseline and 120 minutes after drinking	changes in glucose level after ingest carbohydrate drink or water
thirst and hunger level	baseline and 120 minutes after drinking	thirst and hunger level will be evaluated by visual rating scale
time to empty gastric antrum	baseline and 120 minutes after drinking

Trial Locations

Locations (1)

Department of Anesthesiology, Faculty pf Medicine; 🇹🇭 Songkhla, Thailand