Restoring Iron Deficiency in POTS (Pilot Study)
- Conditions
- POTS - Postural Orthostatic Tachycardia Syndrome
- Interventions
- Registration Number
- NCT07197905
- Lead Sponsor
- Vanderbilt University Medical Center
- Brief Summary
People with postural orthostatic tachycardia syndrome (POTS) often have low red blood cell volumes and low ferritin in their blood (a marker of iron storage in the body). The purpose of this study is to investigate whether giving iron to people with POTS who have low ferritin levels will increase the red blood cell volume and improve POTS symptoms.
- Detailed Description
The study involves undergoing a physical exam and medical history, answering some questionnaires, and visiting the Vanderbilt Autonomic Dysfunction Center before and 2 months after the iron treatment for bloodwork, blood volume measurements, autonomic function tests, and wearing an activity monitor.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 12
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Intravenous Iron Infusion Intravenous iron The Intravenous iron infusion will be administered according to standard clinical care.
- Primary Outcome Measures
Name Time Method Orthostatic tachycardia Orthostatic tachycardia will be assessed before iron infusion (Visit 1) and after 2 months of treatment (Visit 2) Orthostatic tachycardia, defined as the difference between upright and supine heart rates, will be assessed during a 10-minute head-up tilt test.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Autonomic Dysfunction Center/ Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Autonomic Dysfunction Center/ Vanderbilt University Medical Center🇺🇸Nashville, Tennessee, United States