Blood Eosinophil Measurements Throughout the Day in Patients With Stable Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Within-day within-subject level changes of blood eosinophils
研究概览
简要总结
This study will assess the within-day variation of blood eosinophils in patients with Chronic Obstructive Pulmonary disease (COPD) in stable state and determine if there is a correlation between the blood eosinophils and certain clinical parameters.
详细描述
COPD is a heterogeneous disease, resulting in different phenotypes with varying clinical and pathophysiological characteristics. One of these pathophysiological features is chronic airway inflammation which can be eosinophilic of nature. Blood eosinophils could be an accessible biomarker for this eosinophilic inflammation.
Eosinophil counts can fluctuate due to their short half-life in blood and due to a diurnal rhythm. More needs to be known about this diurnal rhythm and the different confounding factors and sources of within-subject variability of this biomarker.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients willing and able to give informed consent for participation in the study.
- •Age 18 years or older.
- •Diagnosis of COPD according to GOLD (Global Initiative for Chronic Obstructive Lung Disease): post-bronchodilator Tiffeneau index <0.7), in a stable state of the disease.
- •A smoking history of >10 pack-years
- •Exclusion criteria:
- •Clinical diagnosis of asthma.
- •Use of systemic corticosteroids (oral, intravenous or infiltration) up to six weeks before inclusion.
- •Pregnancy.
- •A recent exacerbation of COPD (<4 weeks).
排除标准
- 未提供
结局指标
主要结局
Within-day within-subject level changes of blood eosinophils
时间窗: 12 hours
Describe the within-day within-subject levels of blood eosinophils and determine the within-day within-subject variability of blood eosinophils
次要结局
未报告次要终点