Effect of altering inspired oxygen concentrations on cerebral oxygenation during awake carotid surgery - O2 and cerebral oximetry during awake CEA
- Conditions
- Carotid endarterectomy is an operation performed on patients with a symptomatic stenosis of the internal carotid artery. Such patients have usually presented with stroke or transient ischaemic attack. The degree of stenosis is estimated by Doppler ultrasound. Patients are only operated on if there is 70-99% stenosis.
- Registration Number
- EUCTR2005-004209-27-GB
- Lead Sponsor
- Oxford Radcliffe Hospitals NHS Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
All patients undergoing carotid endarterectomy under regional anaesthesia
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Patient refusal for regional anaesthesia
Patient refusal to participate in the trial
Non-English speaking (this would preclude regional anaesthesia techniques anyway)
Complete contralateral internal carotid artery occlusion
Inability to apply bilateral sensors to patient's forehead
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To investigate whether increasing the inspired oxygen concentration improves cerebral oxygenation during the period of carotid cross-clamping in patients undergoing carotid endarterectomy (CEA) under regional anaesthesia.;Secondary Objective: ;Primary end point(s): Patient participation in the trial is concluded at the end of surgery when all readings have been obtained
- Secondary Outcome Measures
Name Time Method