biomarkers in the diagnosis and prognosis in septic acute kidney injury

Not Applicable

Completed

• Conditions: sepsis; acute renal injury; Renal and Urogenital - Kidney disease; Infection - Other infectious diseases; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12614001284651
• Lead Sponsor: Dr. Hsin-I Tsai

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-12-09
• Study Completion: 2015-06-30
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

>18 years old without known previous renal diseases admitted to our surgical ICU in the absence of any one of the exclusion criteria

Exclusion Criteria

1.Urinary tract infection on admission
2.Chronic kidney disease (glomerular filtration rate <60ml/min/1.73m2) for more than 3 months)
3.Patients requiring routine dialysis program
4.Renal transplantation
5.Inflammatory bowel disease

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
serum and urine concentrations of biomarkers(NGAL,IL-18, KIM-1, calprotectin),corresponding to the progression/regression of AKI<br>[from admission and then every other day during ICU stay until discharge from ICU or death]

Secondary Outcome Measures

Name	Time	Method
prediction of AKI development on admission to ICU; AKI will be defined using RIFLE criteria and patients' RIFLE status will be assessed on the same day as the urine/blood samples are obtained[concentration of serum and urine biomarkers on ICU admission; concentration will be assessed using appropriate ELISA kit for each biomarker]