Local Anaesthetic for Transvaginal Egg Collection in IVF

Not Applicable

Completed

• Conditions: Infertility
• Interventions: Drug: lignocaine; Drug: normal saline

• Registration Number: NCT00554424
• Lead Sponsor: The Fertility Centre, New Zealand

Brief Summary

The purpose of this study is to see whether injecting local anaesthetic into the vaginal tissues,just prior to transvaginal egg collection,will decrease the amount of pain experienced by women having their eggs collected on an IVF cycle. All women will also receive intravenous sedation as required as well as a sleeping tablet thirty minutes prior to the procedure which is our routine procedure for egg collection.

Detailed Description

Transvaginal oocyte retrieval is the most common method of oocyte collection in IVF cycles. A variety of different methods are used to provide analgesia/anesthesia for oocyte collection. Our unit has always used an oral pre-medication followed by intravenous fentanyl during the procedure but this doesn't seem to provide adequate analgesia for some women. The aim of this study was to compare the addition of intravaginal local anaesthetic injection versus saline placebo to our usual analgesia regime to see whether less intravenous fentanyl was required and whether the women experienced less pain during oocyte collection.

Study Timeline

• Study Start: 2002-03
• Study Completion: 2002-07
• Status Verified: 2007-11
• Study First Submitted: 2007-11-03
• Study First Submitted QC: 2007-11-05
• Last Update Submitted: 2007-11-05
• Study First Posted: 2007-11-06
• Last Update Posted: 2007-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 75

Inclusion Criteria

• About to undergo transvaginal oocyte retrieval

Exclusion Criteria

• Already undergone oocyte retrieval and participated in study (i.e. 2nd or more oocyte collection procedure during study period)
• Allergy to lignocaine
• Oocytes only to be collected from one ovary
• Procedure expected to be exceptionally painful

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
LA	lignocaine	Intravaginal and pre-peritoneal injection of 1% lignocaine into each side of the upper vagina under ultrasound guidance immediately prior to ultrasound guided transvaginal oocyte retrieval
P	normal saline	Intravaginal saline placebo injection into each side of upper vagina under ultrasound guidance immediately prior to transvaginal oocyte retrieval

Primary Outcome Measures

Name	Time	Method
Total dose of iv fentanyl used during oocyte collection	Length of oocyte collection (minutes)

Secondary Outcome Measures

Name	Time	Method
Pain score (cm on a Visual Analogue Scale) at 6 different points during oocyte collection	Actual point in time
Length of oocyte collection procedure	Time taken (minutes)
Occurence of nausea or vomiting	During oocyte collection procedure
Administration of atropine or anti -emetic	During oocyte collection procedure
Time spent in recovery room	Time from end of oocyte collection until discharge home
No of oocytes collected	During oocyte collection procedure
Number of oocytes fertilised	Assessed 18 hours after oocyte collection
Pregnancy outcome	7 weeks gestation
Number of embryos frozen	Within 6 days of oocyte collection
Pulse rate at beginning and end of egg collection	Point in time
Maximum pulse rate during oocyte collection	Point in time during oocyte collection procedure

Trial Locations

Locations (1)

The Fertility Centre; 🇳🇿 Christchurch, Canterbury, New Zealand