Post - Hospital Syndrome: Profile of Functional Status by Malnutrition

• Conditions: Sarcopenia; Malnutrition

• Registration Number: NCT03126500
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

Malnutrition is common problem in hospitalized geriatrics at discharge. Malnutrition is a high risk for functional limitations, impaired muscle strength and reduced quality of life.

Detailed Description

The majority of geriatric hospitalized patients are at high risk for malnutrition at discharge, which has negative impact on post-hospital outcomes. In a cross-sectional analysis in malnourished, geriatric patients we will evaluate frailty-status and functional status using objective and subjective methods at hospital discharge. Moreover, we will investigate the association between nutritional Status and frailty, sarcopenia, quality of life and fatigue.

Study Timeline

• Study First Submitted: 2017-04-12
• Study First Submitted QC: 2017-04-20
• Study First Posted: 2017-04-24
• Study Start: 2017-05-31
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-27
• Last Update Posted: 2020-01-28
• Primary Completion: 2021-04-30
• Study Completion: 2021-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Age ≥ 60 years
• Informed written consent
• Existing or risk of malnutrition
• Normal cognitive status according to Mini-Mental State Examination (MMSE ≥ 24 points)
• Life expectancy of > 3 months according to treating doctor

Exclusion Criteria

• Age < 60 years
• Lack of informed written consent
• No risk of malnutrition
• Low cognitive status according to Mini-Mental State Examination (MMSE < 24 points)
• Life expectancy of < 3 months according to treating doctor

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Functional Parameter: gait speed	Baseline (hospital discharge)	gait analysis

Secondary Outcome Measures

Name	Time	Method
Strength Parameter: Knee extension strength	Baseline (hospital discharge)	Knee extension strength measurement
Body composition	Baseline (hospital discharge)	bioelectric impedance Analysis
Frailty-Status	Baseline (hospital discharge)	Fried criteria
Functional Parameter: timed up & go (TUG) time	Baseline (hospital discharge)	timed up \& go (TUG) test
Functional Parameter: stair climbing time	Baseline (hospital discharge)	stair climbing test
Index of quality of life	Baseline (hospital discharge)	validated questionnaire
Functional Parameter: Peak expiratory flow rate	Baseline (hospital discharge)	peak flow meters scale
Strength Parameter: Hand grip strength	Baseline (hospital discharge)	Hand grip strength measurement

Trial Locations

Locations (1)

Charite University, Berlin, Germany; 🇩🇪 Berlin, Germany