Effect of Anesthesia on Quality of Recovery in Patients Undergoing Correctional Tibial Osteotomy - A Randomized Controlled Trial

Not Applicable

Completed

• Conditions: Osteoarthritis; Short Stature
• Interventions: Drug: propofol and remifentanil; Drug: desflurane and remifentanil

• Registration Number: NCT02826902
• Lead Sponsor: Yonsei University

Brief Summary

The effect of total intravenous anesthesia (TIVA) versus inhalational anesthesia on the quality of recovery from surgery has been reported in several different types of operations. The Quality of Recovery 40 (QoR-40) questionnaire is designed multi-dimensionally to assess the degree of recovery after anesthesia and surgery, and has been validated in previous studies. The present study aims to compare the quality of recovery with the QoR-40 questionnaire, in patients undergoing correctional tibial osteotomy under general anesthesia with either TIVA with propofol or inhalational anesthesia with desflurane.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-07-06
• Study First Submitted QC: 2016-07-07
• Study First Posted: 2016-07-11
• Study Start: 2016-09-27
• Primary Completion: 2019-11-09
• Study Completion: 2019-11-09
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-13
• Last Update Posted: 2020-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

1. Adult patients over the age of 19 scheduled for cosmetic lower limg lengthening for short stature, or correctional tibial osteotomy for osteoarthritis

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Exclusion Criteria

1. Patient refusal
2. Patients with altered mental status
3. Ejection fraction under 55%
4. Recent MI, CVA, or major cardiovascular surgery
5. 3rd degree AV block, 2nd degree AV block with P:QRS ration greater than 3:1
6. Hemodynamically unstable patients requiring vasopressors or oxygen therapy
7. Febrile patients
8. Patients with decreased renal function (serum Cr > 0.1 mg/dL)
9. Patients with known allergies to propofol
10. Pregnant patients

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TIVA group	propofol and remifentanil	-
Inhalation anesthesia group	desflurane and remifentanil	-

Primary Outcome Measures

Name	Time	Method
QoR-40 score	24 hours after surgery

Secondary Outcome Measures

Name	Time	Method
QoR-40 score	preoperative period to 48 hours after surgery

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine; 🇰🇷 Seoul, Korea, Republic of