A Translational Understanding of Obesity-Related Phenotypes Using Brain Imaging and Manipulation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Baseline lateral prefrontal cortex oxygenated hemoglobin
研究概览
简要总结
This study will examine a potential relationship between family history of obesity, that is whether people with at least one parent who had obesity in adulthood compared to people with two parents who did not have obesity in adulthood, and the ability of protein intake to curb further intake of food.
详细描述
- Abstract of the study A positive energy balance (greater intake than expenditure) can explain weight gain and, when protracted, leads to overweight and obesity. The major question addressed in this proposal is if the timing of activation of specific regions of the brain is predictive of excessive food intake. Functional near infra-red spectroscopy (fNIR), seldom used in human eating studies, provides data similar to functional magnetic resonance imaging (fMRI) but allows for measurement of brain activation during food consumption. The investigator's pilot fNIR data reveal that varying patterns of regional PFC activation are associated with "loss of control" over eating, and that only 60% of individuals respond to acute protein intake with a reduction in food intake. Using fNIR and an acute protein challenge, the investigator will assess the effect of family history of obesity in humans on the satiation response to protein and concomitant activation of the prefrontal cortex (PFC). It is hypothesized that activation of the human medial PFC before the lateral PFC will result in greater intake of palatable food in those subjects with a proneness to obesity, and that these subjects will be less sensitive to the satiety-inducing effects of a protein preload. These results should provide an innovative and useful method for assessing risk for developing obesity and usefulness of preventative interventions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
Participants consume two preloads one at each visit, but are not informed which preload is being consumed on which test visit.
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Baseline lateral prefrontal cortex oxygenated hemoglobin
时间窗: 20 minutes
Micromoles per millimeter of oxygenated hemoglobin of the lateral prefrontal cortex prior to pizza consumption
lateral prefrontal cortex Oxygenated hemoglobin concentration
时间窗: 3-15 minutes
Micromoles per millimeter of oxygenated hemoglobin of the lateral prefrontal cortex during pizza consumption phase
Baseline medial prefrontal cortex oxygenated hemoglobin
时间窗: 20 minutes
Micromoles per millimeter of oxygenated hemoglobin of the medial prefrontal cortex prior to pizza consumption
Grams of pizza consumed
时间窗: 3-15 minutes
Ad libitum during the pizza eating episode
medial prefrontal cortex Oxygenated hemoglobin concentration
时间窗: 3-15 minutes
Micromoles per millimeter of oxygenated hemoglobin of the medial prefrontal cortex during pizza consumption phase
次要结局
- lateral prefrontal cortex Time to Peak Light Intensity(3-15 minutes)
- medial prefrontal cortex Time to Peak Light Intensity(3-15 minutes)
- Preload Oxygenated Hemoglobin Difference(5 minutes)