eurocognitive functioning and brain plasticity in high-grade glioma patients: a magnetoencephalography pilot

• Conditions: glioblastoma multiforme (high-grade glioma)

• Registration Number: NL-OMON23187
• Lead Sponsor: VU University Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

For newly diagnosed patients:
1. Adult (> 18 years),
2. Radiologically suspected GBM prior to surgery,
3. histologically confirmed GBM after surgery,
4. treatment consisting of surgery followed by combined radiotherapy and chemotherapy,
5. written informed consent.
For patients with GBM recurrence:
1. adult (> 18 years),
2. histologically confirmed GBM,
3. treatment consisting of surgery followed by chemotherapy,
4. written informed consent.
For matched healthy controls:
1. adult (> 18 years),
2. written informed consent.

Exclusion Criteria

For patient groups:
1.use of centrally acting drugs, including corticosteroids, other than
antiepileptic drugs,
2. psychiatric disease or symptoms,
3. insufficient mastery of the
Dutch language,
4. inability to communicate adequately.
For controls:
1. use of centrally acting drugs (including analgetics),
2. psychiatric disease or symptoms,
3. disorders of the central nervous system, 4. insufficient mastery of the Dutch language.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main study parameters are neurocognitive functioning and MEG-measures (synchronization likelihood and small-world features).

Secondary Outcome Measures

Name	Time	Method
ot applicable.