Swiss Longitudinal Cohort

Recruiting

• Conditions: Cardiovascular Risk Factors

• Registration Number: NCT02282748
• Lead Sponsor: Hypertension Excellence Centre Lucerne

Brief Summary

The planned research project is a prospective population-based cohort study, similar to the well-known Framingham study in the United States. So far, there is no similar research project in Switzerland.

It is planned to examine of three Swiss municipalities. Recruitment in a first Swiss municipality (Lostallo/Cama GR) started 2014 and ended in 2019. Overall, 496 participants were recruited in this municipality. The five-year follow-up in this municipality started in 2019. It is planned to start recruitment in a second Swiss municipality (Uznach SG) in 2020.

The examinations embrace a broad spectrum of measurements (for details the investigators refer to the published study protocol).

Detailed Description

Not available

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2014-10-29
• Study First Submitted QC: 2014-10-31
• Study First Posted: 2014-11-04
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-14
• Last Update Posted: 2020-02-18
• Primary Completion: 2024-09
• Study Completion: 2034-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Resident of Cama GR, Lostallo GR, or Uznach SG
• Age ≥6 years (no upper age limit), for voluntary blood sample ≥18 years
• Willing to participate in long-term study
• Written informed consent (in participants ≥6 years and <18 years signed by parents)

Exclusion Criteria

• No exclusion criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality	10 years

Secondary Outcome Measures

Name	Time	Method
Heart function	10 years	Heart function will be assessed using questionnaires for symptoms, clinical examination and measurement of electromechanical activation time.
Cognitive function	10 years	Cognitive function will be assessed using validated instruments.
Nursing home admission	10 years	Nursing home admissions will be assessed using standardized questions.
Cardiovascular events	10 years	Cardiovascular events (i.e. stroke, myocardial infarction) will be assessed using questionnaires and case records.
Autonomy	10 years	Autonomy wil be assessed using validated instruments.
Kidney function	10 years	Kidney function will be assessed using laboratory measurements.

Trial Locations

Locations (3)

Cama; 🇨🇭 Cama, Graubünden, Switzerland

Lostallo; 🇨🇭 Lostallo, Graubünden, Switzerland

Linth Hospital; 🇨🇭 Uznach, Saint Gallen, Switzerland