Air Pollution, Inflammation and Acute Coronary Syndrome

Completed

• Conditions: Patients With Acute Coronary Syndrome
• Interventions: Other: Particulate air pollutants

• Registration Number: NCT01799148
• Lead Sponsor: Fundación Canaria Rafael Clavijo para la Investigación Biomédica

Brief Summary

The objectives of this study are: 1) To determine whether patients with acute coronary syndrome, the level of environmental exposure to particulate air pollutants in the week prior to admission, are related to concentrations of inflammatory molecules and oxidative stress. 2) To investigate whether the level of environmental exposure is an independent prognostic factor in terms of overall and cardiovascular mortality, myocardial infarction or unstable angina at 30 days, 6 and 12 months.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2013-02-23
• Study First Submitted QC: 2013-02-25
• Study First Posted: 2013-02-26
• Primary Completion: 2014-07
• Study Completion: 2014-11
• Status Verified: 2015-01
• Last Update Submitted: 2015-01-19
• Last Update Posted: 2015-01-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 307

Inclusion Criteria

• Patients with acute coronary syndrome

Exclusion Criteria

• Infectious process and / or local or systemic inflammation in the 15 days before admission.
• Thyrotoxicosis.
• Neoplasms - or any other disease that seriously compromise the prognosis of life and / or generate a systemic inflammatory response.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Particulate air pollutants	Particulate air pollutants	Cohort of consecutive patients admitted with diagnosis of acute coronary syndrome in the cardiology unit of a tertiary hospital, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission.

Primary Outcome Measures

Name	Time	Method
Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome.	7 days	A single center, cohort of consecutive patients admitted with diagnosis of acute coronary syndrome in the cardiology unit of a tertiary hospital, which will quantify the exposure of particulate air pollutants 24 hours a day 7 days earlier prior to admission. Also be determined inflammatory molecules and oxidative stress in admission.

Secondary Outcome Measures

Name	Time	Method
Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary syndrome.	1 year	During the evolution of these patients, after 30 days, 6 and 12 months will recorded major adverse cardiovascular events. It also will quantify the exposure of air pollutant particles in all patients included, at 30 days, 6 and 12 months.

Trial Locations

Locations (1)

Hospital Universitario de Canarias; 🇪🇸 La Laguna, Santa Cruz de Tenerife, Spain