Effect of Air Pollution on Prognosis of Patients With Chronic Obstructive Pulmonary Disease and Its Underlying Biological Mechanism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Lung function
研究概览
简要总结
This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.
详细描述
This panel study was conducted in a group of stable patients with COPD in Beijing, China. The health measurements including lung function, blood pressure and airway inflammation were conducted, and morning urine, exhaled breath condensate, saliva and venous blood were collected at the time of enrollment and at 3, 6 and 9 months after enrollment. Individual exposures to fine particulate matter (PM2.5), black carbon (BC), ozone (O3) and nitrogen dioxide (NO2) were performed for 24 hours at each follow-up. And the daily concentrations of air pollutants were collected from the Beijing Air Quality Real-time Publishing Platform and meteorological data were collected from the National Meteorological Information Center. The linear mixed effects model was used to analyze the association between air pollution and cardiopulmonary health in patients with COPD.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •doctor-diagnosed stable COPD patients
- •aged 40 to 80 years
- •lived in Beijing for over one year before being recruited
- •Agree to participate and sign the informed consent form.
排除标准
- •Patients with a history of acute exacerbation in the last 1 month
- •Patients with other respiratory diseases such as bronchiectasis and asthma.
结局指标
主要结局
Lung function
时间窗: Nine months
Lung function test was conducted.
次要结局
- Modified British Medical Research Council (mMRC) Questionnaire score(Nine months)
- ST. George's Respiratory Questionnaire scores(Nine months)
- Blood pressure(Nine months)
- Respiratory inflammation(Nine months)
- Systemic inflammation(Nine months)
- COPD Assessment Test scores(Nine months)
- Airway and systemic oxidative stress levels(Nine months)
研究者
Furong Deng
Deputy Director of Department of Occupational and Environmental Health Sciences
Peking University