Metabolomics Identifies Increases in Acylcarnitine Profiles in Plasma of Overweight Subjects in Response to Mild Weight Loss
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Visceral fat area at L4 (CT)
研究概览
简要总结
To determine whether low calorie diet (LCD)-induced weight reduction caused changes in plasma metabolites and metabolic traits from baseline.
详细描述
Over a 12-week clinical intervention period, a randomized, controlled study was carried out; overweight subjects consumed a LCD (approximately 300kcal/d deficit, n=47) or a weight-maintenance diet (control, n=50) were included for analyzing plasma samples and metabolites using an ultra-performance liquid chromatography and mass spectrometry (UPLC-LTQ/Orbitrap MS).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to give informed consent
- •20-65 years old
- •Males and females
- •Overweight (25.0 kg/m²≤ Body mass index <30 kg/m²)
- •Nondiabetic (Fasting glucose <126 mg/dL)
排除标准
- •Unstable body weight (body weight change >1 kg within 3 months before screening)
- •Consumption of medication that affects body weight or energy expenditure
- •Pregnancy or breast-feeding
- •Hypertension, type 2 diabetes, cardiovascular disease, cerebrovascular disease, or thyroid disease
- •Liver disease, kidney disease, or gastrointestinal disease
- •Acute or chronic infections
- •Any acute or chronic disease requiring treatment
结局指标
主要结局
Visceral fat area at L4 (CT)
时间窗: At 12-week follow-up
Change in visceral fat area at L4 from baseline
时间窗: At baseline and 12-week follow-up
Putatively identified plasma metabolites (Normalized peak intensities)
时间窗: At 12-week follow-up
Changes in putatively identified plasma metabolites (Normalized peak intensities) from baseline
时间窗: At baseline and 12-week follow-up
次要结局
未报告次要终点