Effects of Dieatry Fiber on Insulin Sensitivity in Pre- and Post-menopausal Women
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Insulin sensitivity
研究概览
简要总结
This study will examine the effects of a dietary fiber on insulin sensitivity in overweight and obese women. The fiber will be added to snack foods and women will consume the foods for four weeks. In one four-week period, 15 g of fiber will be added, and 30 g will added in another period. In a third period, no fiber will be added to the snack foods. Insulin senstivity will be measured at the end of each treatment period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Impaired fasting glucose
- •Overweight and obese
排除标准
- •Diabetes, Presence of chronic diseases
研究组 & 干预措施
Low dose
15 g of fiber per day will be added to snack foods
干预措施: Dietary Fiber (Dietary Supplement)
High dose
30 g of fiber per day will be added to snack foods
干预措施: Dietary Fiber (Dietary Supplement)
No fiber
Snack foods without fiber will be given
干预措施: Dietary Fiber (Dietary Supplement)
结局指标
主要结局
Insulin sensitivity
时间窗: 5-hr test, performed 3 times within a 20-week period
A frequently sampled intravenous blood glucose tolerance test will be performed.
次要结局
- Mitocondrial function(3 times, with a 20-week period)
- Meal tolerance test(3 times, within a 20-week period)