Potential antioxidant effects of a natural clinoptilolite zeolite/sea buckthorn (ZSB) dietary supplement on smokers with stressful life styles
- Conditions
- We have examined the antioxidant status of healthy volunteers who were smokers, followed an unhealthy diet as defined by the consumption of junk food at least 3 times per week and were doing stressful (office) jobs. The subjects reported also minimal levels of physical exercise as defined by walking less than one mile per day.Mental and Behavioural Disorders
- Registration Number
- ISRCTN11812295
- Lead Sponsor
- Medicines from Earth LTD
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
1. Healthy Caucasian volunteers (20 males, 37 ± 6.3 year old, with body mass index (BMI) 28.2 ± 1.6) who were following a non-healthy type of diet as defined by the consumption of junk food at least 3 times on a weekly basis were recruited from a relatively young population of patients who have been visiting during 2014 an outpatient medical clinic of a university hospital for routine check-up purposes
2. All patients were smokers (15 packs. yr ± 2.7)
3. All were doing stressful (office) jobs
4. Level of physical exercise was minimal as defined by walking less than a mile/day
5. All patients provided formal informed consent to participate in the study which was approved by the institutional ethics committee
1. Any recorded active medical disorder
2. History of cardiovascular disease or any other systemic inflammatory disorder
3. Abnormal lipid blood profiles
4. Age over 65 years old
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the anti-oxidant properties of ZSB by measuring the total antioxidant status (TAS) and the thiobarbituric acid reactive substances (TBARS) test in cases and controls.
- Secondary Outcome Measures
Name Time Method <br> 1. Any potential side effects following the administration of ZSB. Patients were followed every 15 days by means of total blood counts and regular biochemical studies including urea, creatinine, and hepatic enzymes<br> 2. Patient self-evaluation (via a questionnaire) of any potential changes in their smoking/dietary habits, level of physical activity (walking miles per day) and stress levels. Stress levels were assessed by means of a semi-quantitative scale (1 to 10; whereas 1 indicated no stress and 10 high stress levels).<br>