Lung Tumor Protein Synthesis Rates in Lung Cancer Patients

Recruiting

• Conditions: Lung Cancer

• Registration Number: NCT05794529
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

The current study will recruit lung cancer patients to measure tissue protein synthesis rates of non-small cell lung carcinomas and healthy lung tissue. The protein synthesis rates of healthy lung tissue will be compared to lung tumor tissue to establish the remodeling characteristics of healthy versus cancerous lung tissues. We will also examine whether tissue protein synthesis rates of non-small cell lung carcinomas are associated with various tumor- (i.e., size, subclassification) and patient-derived (i.e., inflammation, lung function, smoking status, and smoking history) parameters.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-03
• Study Start: 2023-03
• Study First Submitted: 2023-03-15
• Study First Submitted QC: 2023-03-31
• Last Update Submitted: 2023-03-31
• Study First Posted: 2023-04-03
• Last Update Posted: 2023-04-03
• Primary Completion: 2026-03
• Study Completion: 2026-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Aged 18-65 years
2. Compos mentis
3. Diagnosed with lung cancer, with treatment requiring a thoracotomy or VATS lobectomy

Exclusion Criteria

1. Neoadjuvant chemo- or radiotherapy in the past four weeks
2. Use of systemic steroids in the past four week
3. Insulin-dependent diabetes mellitus
4. Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Lung tumor fractional synthetic rate	5 days prior to surgery	units: % per day
Lung tissue fractional synthetic rate	5 days prior to surgery	units: % per day
Muscle tissue fractional synthetic rate	5 days prior to surgery	units: % per day

Secondary Outcome Measures

Name	Time	Method
Plasma GH concentrations	Baseline	units: mU/L
Plasma TNF-alpha concentrations	Baseline	units: ng/L
Plasma CRP concentrations	Baseline	units: mg/L
Plasma IL-6 concentrations	Baseline	units: ng/L
Plasma IGFBP-1 concentrations	Baseline	units: ug/L
Plasma insulin concentrations	Baseline	units: pmol/L
Plasma IL-1 concentrations	Baseline	units: ng/L
Plasma IGF-1 concentrations	Baseline	units: nmol/L
Plasma IGFBP-3 concentrations	Baseline	units: ug/L
Plasma IL-10 concentrations	Baseline	units: ng/L
Plasma glucose concentrations	Baseline	units: mmol/L

Trial Locations

Locations (1)

Zuyderland Medical Center; 🇳🇱 Heerlen, Limburg, Netherlands