Characterizing Tissue Protein Synthesis Rates of Non-small Cell Lung Carcinomas in Lung Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Lung tumor fractional synthetic rate
研究概览
简要总结
The current study will recruit lung cancer patients to measure tissue protein synthesis rates of non-small cell lung carcinomas and healthy lung tissue. The protein synthesis rates of healthy lung tissue will be compared to lung tumor tissue to establish the remodeling characteristics of healthy versus cancerous lung tissues. We will also examine whether tissue protein synthesis rates of non-small cell lung carcinomas are associated with various tumor- (i.e., size, subclassification) and patient-derived (i.e., inflammation, lung function, smoking status, and smoking history) parameters.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 18-65 years
- •Compos mentis
- •Diagnosed with lung cancer, with treatment requiring a thoracotomy or VATS lobectomy
排除标准
- •Neoadjuvant chemo- or radiotherapy in the past four weeks
- •Use of systemic steroids in the past four week
- •Insulin-dependent diabetes mellitus
结局指标
主要结局
Lung tumor fractional synthetic rate
时间窗: 5 days prior to surgery
units: % per day
Lung tissue fractional synthetic rate
时间窗: 5 days prior to surgery
units: % per day
Muscle tissue fractional synthetic rate
时间窗: 5 days prior to surgery
units: % per day
次要结局
- Plasma GH concentrations(Baseline)
- Plasma TNF-alpha concentrations(Baseline)
- Plasma CRP concentrations(Baseline)
- Plasma IL-6 concentrations(Baseline)
- Plasma IGFBP-1 concentrations(Baseline)
- Plasma IGFBP-3 concentrations(Baseline)
- Plasma IL-10 concentrations(Baseline)
- Plasma glucose concentrations(Baseline)
- Plasma insulin concentrations(Baseline)
- Plasma IL-1 concentrations(Baseline)
- Plasma IGF-1 concentrations(Baseline)