Sputum high mobility group box protein levels and clinical features of smear negative pulmonary tuberculosis

Recruiting

• Conditions: Adult (18-70 years old) diagnosed with either acid-fast bacilli (AFB) smear-positive or AFB smear-negative pulmonary tuberculosis.; Tuberculosis; HBMG1; smear negative; pulmonary

• Registration Number: TCTR20240410004
• Lead Sponsor: Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-10
• Study Completion: 2024-05-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Adult (18-70 years old) diagnosed with either acid-fast bacilli (AFB) smear-positive or AFB smear-negative pulmonary tuberculosis.

Exclusion Criteria

Symptoms suggestive of any form of extrapulmonary tuberculosis
Previous treatment or evidence of PTB
Underlying compromising conditions such as recent trauma, HIV/AIDS, active malignancy, autoimmune diseases and long-term immunosuppressant use.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sputum HMBG1 level At enrollment, month 2, month 6 Quantitative test (pg/mL)

Secondary Outcome Measures

Name	Time	Method
Sensitivity of HMBG1 At enrollment, month 2, month 6 Receiver operating characteristic curve,Specificity of HMBG1 At enrollment, month 2, month 6 Receiver operating characteristic curve