Comparison of perineural & intravenous dexamethasone on glycemic profile in non diabetic patients undergoing supraclavicular brachial plexus block
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- The aim of the study is to compare blood glucose concentration in perineural & intravenous dexamethasone group.
研究概览
简要总结
Dexamethasone is a local anesthetic adjuvant andwidely used perineurally to enhance the effects of brachial plexus block.Studies have revealed that dexamethasone can prolong the time of localanesthetic nerve block analgesia. Steroids have nerve block prolonging effectsby blocking transmission of nociceptive myelinated c-fibers and suppressingectopic neuronal discharge.
They are also thought to alter the function ofpotassium channels in the excitable cells. Dexamethasonehas been reported as an excellent adjuvant to enhance the post op analgesia in supraclavicularbrachial plexus block.
Dexamethasone in various doses (4mg to 8mg)has been used. Inperioperative setting, low dose(<10mg) dexamethasone is administeredprimarily for nausea and vomiting prophylaxis.
Dexamethasone has been reported to increaseblood glucose concentration in both diabetic and non-diabetic patients. Thereare varying results of perioperative of dexamethasone on blood glucoseconcentration, some studies have reported no increase in blood glucoseconcentration where as there are few studies that has shown there is increasein blood glucose concentration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •All the Non Diabetic Patients undergoing Supraclavicular brachial plexus block who fit into ASA (American Society Of Anesthesiology) Grade I/II.
排除标准
- •Subjects with pre-existing diabetes mellitus patients (FBS> 126 mg/dl, Post prandial blood sugars (PPBS>200mg/dl).
- •Chronic steroids therapy.
- •History allergy to dexamethasone.
- •Immunosuppressed patients.
- •Patients Refusal.
结局指标
主要结局
The aim of the study is to compare blood glucose concentration in perineural & intravenous dexamethasone group.
时间窗: Finger prick capillary blood sugar values will be measured at baseline before block, after 1 hour,2 hours, 3 hours, 4 hours, 5 hours, 6 hours using glucometer.
次要结局
- To study the duration of post operative analgesia (Visual analogue score4).