Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

Not Applicable

Completed

• Conditions: Complications; Anesthesia; Urinary Bladder Neoplasms; Catheter Site Discomfort
• Interventions: Drug: Sevoflurane; Drug: Desflurane

• Registration Number: NCT02096224
• Lead Sponsor: Seoul National University Hospital

Brief Summary

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Detailed Description

The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The volatile anesthetics such as sevoflurane and desflurane are known to block the muscarinic receptor in different ways.

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Study Timeline

• Status Verified: 2014-03
• Study First Submitted: 2014-03-21
• Study First Submitted QC: 2014-03-21
• Study First Posted: 2014-03-26
• Study Start: 2014-05
• Primary Completion: 2014-07
• Study Completion: 2014-07
• Last Update Submitted: 2014-09-30
• Last Update Posted: 2014-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

• Patients scheduled for transurethral bladder excision under general anesthesia
• ASA I-III

Exclusion Criteria

• Bladder outflow obstruction
• Overactive bladder
• End-stage renal disease
• Neurogenic bladder
• Heart failure
• Arrhythmia
• Morbid obesity
• Use of chronic analgesic medication
• Hepatic disease
• Pulmonary disease
• Psychiatric disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	Sevoflurane will be administered as the maintenance agent of general anesthesia.
Desflurane	Desflurane	Desflurane will be administered as the maintenance agent of general anesthesia.

Primary Outcome Measures

Name	Time	Method
Catheter-related bladder discomfort	24 hour postoperatively	Catheter-related bladder discomfort will be measured for 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).

Secondary Outcome Measures

Name	Time	Method
Vomiting	0, 1, 6 and 24 hour postoperatively	The degree of vomiting will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.
Dry mouth	0 houe after admission of operating room	Dry mouth after the admission of operating room will be assessed. (score:0-10)
Catheter-related bladder discomfort	0, 1, 6 and 24 hour postoperatively	Catheter-related bladder discomfort will be measured at 0, 1, 6 and 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).
Nausea	0, 1, 6 and 24 hour postoperatively	The degree of nausea will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.

Trial Locations

Locations (1)

Seoul National University of Hospital; 🇰🇷 Seoul, Korea, Republic of