Effect of intravenous Dexamethasone on post operative analgesia following Ultrasound guided Transversus Abdominis Plane block in adult patient undergoing laparoscopic cholecystectomy under general anesthesia :Randomised placebo controlled study.
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- ABVIMS and Dr Ram Manohar Lohia Hospital
- Enrollment
- 108
- Locations
- 1
- Primary Endpoint
- Numeric Rating scoring(NRS)
Overview
Brief Summary
This is a randomized placebo-controlled study investigating the effect of intravenous dexamethasone on postoperative analgesia in adult patients undergoing laparoscopic cholecystectomy under general anaesthesia. The study includes two groups (54 patients each), In Group A receives IV dexamethasone along with an ultrasound-guided Transversus Abdominis Plane block using 0.375% ropivacaine and in Group B receives normal saline instead of dexamethasone but the same ultrasound-guided Transversus Abdominis Plane block with 0.375% ropivacaine. The primary outcome is to assess the effect of dexamethasone on postoperative analgesia, measured using the Numerical Rating Scale (NRS) at specific time intervals.The secondary outcomes include evaluating the hemodynamic response and Postoperative Nausea and vomiting (PONV) scores at predetermined time points.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •ASA I and II , BMI Between 18-30kg/m2.
Exclusion Criteria
- •1.Pre-existing coagulation disorders 2.Local infection at the sites of injection.
- •3.Any known drug allergies 4.History of diabetes.
Outcomes
Primary Outcomes
Numeric Rating scoring(NRS)
Time Frame: NRS scoring will be assessed - | 30 min after surgery. | 1 hour after surgery. | 2 hour after surgery. | 3 hour after surgery. | 6 hour after surgery. | 12 hour after surgery. | 24 hour after surgery.
Secondary Outcomes
- 1. Hemodynamic parameters (Pulse Rate, Systolic Blood Pressure ,Diastolic Blood Pressure and Mean Arterial Pressure)
Investigators
Dr Ankita Shekhawat
ABVIMS and Dr Ram Manohar Lohia Hospital New Delhi