Symptomatic Efficacy of Diacerein in Knee Osteoarthritis
Phase 4
Completed
- Conditions
- Knee Osteoarthritis
- Registration Number
- NCT00445276
- Lead Sponsor
- Laboratoires NEGMA
- Brief Summary
Pain is the main symptom of osteoarthritis that motivates medical visits. Diacerhein has already demonstrated its efficacy in knee and/or hip osteoarthritis. This study aims at confirming the efficacy of diacerhein in symptomatic knee osteoarthritis using known and validated criteria and according to the recommendations and guidelines for this kind of study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 500
Inclusion Criteria
- Painful primary osteoarthritis (VAS ≥ 40 mm)
- Radiologically proven (Kellgren & Lawrence grade I to III)
- Requiring the prescription of a symptomatic treatment of pain
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Exclusion Criteria
- Severe associated diseases
- Wash-out: AINS, Coxibs, Paracetamol, anti-osteoarthritic treatments, hyaluronic acid, knee tidal lavage
- Other osteoarticular disease
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method VAS on pain movement, WOMAC A 1.1 section
- Secondary Outcome Measures
Name Time Method WOMAC : total, pain, physical function Paracetamol consumption Global assessment of the patient Responder patients with OMERACT-OARSI criteria Tolerance
Trial Locations
- Locations (1)
Chu Trousseau
🇫🇷Tours, France