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Clinical Trials/NCT04388865
NCT04388865
Completed
Not Applicable

Clinical Hovering to Improve Patient Engagement in Inflammatory Bowel Disease

University of Pennsylvania1 site in 1 country150 target enrollmentFebruary 23, 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Inflammatory Bowel Diseases
Sponsor
University of Pennsylvania
Enrollment
150
Locations
1
Primary Endpoint
Short Inflammatory Bowel Disease Questionnaire (SIBDQ) response
Status
Completed
Last Updated
3 years ago

Overview

Brief Summary

This is a 2-arm randomized trial aimed at leveraging behavioral science principles to improve patient engagement between office visits among patients with inflammatory bowel disease (IBD).

Detailed Description

Crohn's Disease (CD) and Ulcerative Colitis (UC), collectively known as inflammatory bowel disease (IBD), are common chronic gastrointestinal diseases with significant morbidity and decreased quality of life. Care for patients with IBD has been transformed by biologic therapies which dramatically improve inflammation and clinical outcomes. As they are delivered through infusion or injection with long intervals between doses, it can be challenging for patients to maintain adherence due to systems issues such as prior authorization and site of service limitations, in addition to traditional reasons for non-adherence such as inertia and present-time bias. Despite evidence that high adherence is needed for effectiveness, estimates are as low as 66%. Preliminary observations and interviews show that an important gap for providers is lack of knowledge of how their patients are doing between visits. Specifically, patients may not adhere to necessary therapy, and physicians are unaware of changes in course of the disease. A large cross-sectional study has shown that patient-reported outcomes are associated with control of the disease, but serially monitoring these measures has not been tested prospectively. A prior study found that assessing symptoms weekly is highly correlated with information collected with a more cumbersome daily diary. This may provide additional data to clinicians to better manage symptoms and therapy. Text messaging is an attractive tool to engage with patients due to the high prevalence of cell phones. The investigators will develop and test a new IBD hovering program that improves the care of patients between office visits. The investigators will enroll patients prescribed biologic therapy and provide text message reminders about scheduled infusions or injections that incorporate behavioral science principles such as anticipated regret, precommitment, and reciprocity. The investigators will also have the patient identify a friend or family member to serve as a support partner to encourage adherence and provide assistance as needed. The platform will communicate with patients weekly to ask about the course of their symptoms, send messaging to the feedback partner, and send alerts to physicians as needed.

Registry
clinicaltrials.gov
Start Date
February 23, 2021
End Date
January 10, 2023
Last Updated
3 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Shivan J Mehta

Assistant Professor of Medicine

University of Pennsylvania

Eligibility Criteria

Inclusion Criteria

  • Diagnosis of Crohn's Disease or Ulcerative Colitis
  • Has had at least 2 visits with Penn Gastroenterology in the past 2 years
  • Currently prescribed a biologic therapy (infliximab, adalimumab, ustekinumab, certolizumab, golimumab, or vedolizumab). Of note, this study is not limited to new initiators of these medications.

Exclusion Criteria

  • Patients will be excluded if they do not have a phone with text messaging.

Outcomes

Primary Outcomes

Short Inflammatory Bowel Disease Questionnaire (SIBDQ) response

Time Frame: 4 months

The change in patient response to the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), which is a 10 question validated instrument to measure quality of life in IBD patients.

Secondary Outcomes

  • Patient Satisfaction(4 months)
  • Medication Adherence(4 months)

Study Sites (1)

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