The Impact of Higher Positive End Expiratory Pressure on Patient Ventilator Asynchrony

Not Applicable

Recruiting

• Conditions: Acute Respiratory Distress Syndrome

• Registration Number: JPRN-UMIN000042319
• Lead Sponsor: Osaka University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-11-05
• Study Completion: 2022-03-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

1) Lack of informed consent 2) Continuous neuromuscular blockade at enrollment 3) DNR (do-not-resuscitate) 4) Moribund patient not expected to survive 24 hours 5) Massive hemoptysis 6) Increased intracranial pressure (> 18 mmHg) 7) Existence or high risk of pneumothorax 8) Known pregnancy 9) Actual body weight exceeding 1 kg/cm 10) Patient judged to be inappropriate for the trial by intensivist

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Asynchrony index of all types of patient ventilator asynchrony at higher and lower PEEP.

Secondary Outcome Measures

Name	Time	Method
1. Asynchrony index of each types of patient ventilator asynchrony at higher and lower PEEP. 2. The intensity of spontaneous breathing effort at higher and lower PEEP 3. Minute volume at higher and lower PEEP. 4. The efficiency of diaphragmatic contraction at higher and lower PEEP.