3 Airway Clearance Techniques in Non Cystic Fibrosis Bronchiectasis

Not Applicable

Completed

• Conditions: Bronchiectasis
• Interventions: Other: Autogenic drainage; Other: Slow expiration with glottis opened in lateral posture; Other: Temporary-positive expiratory pressure

• Registration Number: NCT01854788
• Lead Sponsor: Hospital Clinic of Barcelona

Brief Summary

Study design: a randomized, crossover trial. Each patient performed three different airway clearance techniques (Autogenic drainage, slow expiratory with glottis opened in lateral posture \[ELTGOL\], temporary- positive expiratory pressure \[T-PEP\] with not similar autonomy degree in a randomized order. Each technique were applied in 3 sessions during one week at alternate days (Monday /Wednesday/Friday or Tuesday/Thursday/Saturday). The time spent in each bronchial session was 40 minutes. Seven days were the wash-out time period between the different techniques.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-09
• Primary Completion: 2012-06
• Study Completion: 2012-08
• Study First Submitted: 2012-08-08
• Status Verified: 2013-05
• Study First Submitted QC: 2013-05-13
• Last Update Submitted: 2013-05-13
• Study First Posted: 2013-05-16
• Last Update Posted: 2013-05-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

1. • Non Cystic Fibrosis bronchiectasis diagnosed by High Resolution Computed Tomographic
2. • Mean sputum production ≥ 15 ml /24h
3. • Clinical stability in the last 6 weeks
4. • Not carrying out regular chest physiotherapy
5. • Forced expiratory volume in 1 second ≥ 30% pred. ; Forced Vital Capacity ≥ 45% pred. and peak expiratory flow >270 L/s

Exclusion Criteria

1. • Smoker or non-smoker form less than 2 years
2. • Cystic fibrosis
3. • Active tuberculosis or sarcoidosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Autogenic drainage	Autogenic drainage	All patients performed all interventions in a randomized order. Each technique was applied in 3 non consecutively sessions during one week. The time spent during the session was 40 minutes
Slow expiration with glottis opened in lateral posture	Slow expiration with glottis opened in lateral posture	All patients performed all interventions in a randomized order.Each technique was applied in 3 non consecutively sessions during one week. The time spent during the session was 40 minutes
Temporary-Positive Expiratory Pressure	Temporary-positive expiratory pressure	All patients performed all interventions in a randomized order. Each technique was applied in 3 non consecutively sessions during one week. The time spent during the session was 40 minutes

Primary Outcome Measures

Name	Time	Method
Weight of sputum expectorated during each airway clearance therapy session	40 minutes	Wet weight sputum production were recollected in one pre-weighted containers. It was measured in grams.
Weight of sputum expectorated 24 hours post each bronchial session	24 hours	Wet weight sputum production were recollected in one pre-weighted containers. It was measured in grams.

Secondary Outcome Measures

Name	Time	Method
Saint George Respiratory Questionnaire (SGRQ)	Change from baseline at 5 weeks	Saint George Respiratory Questionnaire (SGRQ) is a self-completed health-related quality of life questionnaire.It was validated in bronchiectasis. It was administrated at the start and at the end of trial.
Leicester Cough Questionnaire (LCQ)	Changes from baseline arm to 1 week	Leicester Cough Questionnaire is a self-completed quality of life measure of the impact of cough severity. It was validated in bronchiectasis. It was administrated at the start and at the end of each technique.

Trial Locations

Locations (1)

Hospital CLinic; 🇪🇸 Barcelona, Spain